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Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet | Gut


IBSP (pathogenic-like) and IBSH (health-like) subtypes. IBSP microbiomes were enriched in Firmicutes and genes for amino acid and carbohydrate metabolism, but depleted in Bacteroidetes species. IBSH microbiomes were similar to controls.

The clinical response to the low FODMAP diet was greater in IBSP subjects compared with IBSH (p=0.02).


  • It can be helpful to test IBS patients’ Gut Biome before recommending a FODMAP diet.
  • The FODMAP diet can be expected to be most helpful to patients with HIGH fermicutes and LOW bacteroides species.