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Fasting & Blood Pressure, Gut Biome Link

From the Original Article

One of the most widely used animal models of hypertension are spontaneously hypertensive stroke-prone (SHRSP) rats, a line of rats that develop hypertension at six weeks of age, much earlier than control animals. Like hypertensive humans, these rats show gut dysbiosis.

To investigate whether gut dysbiosis contributes to the development of hypertension, the researchers transferred gut microbiota from SHRSP rats to rats with normal blood pressure. The previously healthy rats to develop high blood pressure, pointing towards a causal relationship between gut dysbiosis and hypertension.

Could changing the feeding pattern through fasting reduce the blood pressure of the SHRSP rats?

To test this, the researchers split the SHRSP rats into two groups: one group had unlimited access to food, while the other group was fed only every other day. After nine weeks, the rats that had unlimited access to food had developed high blood pressure, as is expected for the SHRSP model. In contrast, rats that were fed only every other day did not develop high blood pressure.

Faecal Transplant Experiments further demonstrate the causal nature of the Gut Biome

The researchers observed that germ-free rats that had received microbiota from the fasting SHRSP rats had lower blood pressure than germ-free rats that had received microbiota from normal-fed SHRSP rats. With this, the researchers discovered that modulating the gut microbiota

Further Questions
  • Exactly what is the gut dysbiosis, which species?
  • Is there a similar difference between normotensive and hypertensive humans?
  • Does alternate day fasting affect human BP the same for hypertensives?
  • Does the same dysbiosis affect normotensive humans? Could it be an identifiable risk factor/ predictor?
  • Hypertension is strongly age related in humans ==> therefore ==> Is dysbiosis age related?