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Study links high sugar intake to increased risk of breast cancer – suggesting a causal effect not just an association

When it comes to the rising rates of obesity, sugar is deemed a key culprit. But high sugar intake may not only lead to weight gain; a new study claims it can increase the risk of breast cancer and hasten spread of the disease to the lungs … According to the team, previous research has identified a link between dietary sugar intake and risk of breast cancer, with some studies suggesting inflammation may play an important role.

the team set out to assess how sugar intake influenced breast cancer development in mice that were randomized to various diets, including a sucrose-enriched diet, a fructose-enriched diet and a starch-control diet.

Mice fed a diet enriched with sucrose or fructose were more likely to develop breast cancer and have the disease spread to the lungs, according to the results of a new study.

Source: Study links high sugar intake to increased risk of breast cancer – Medical News Today

The 116 things that can give you cancer – the full list … International Agency for Research on Cancer via the Guardian

The 116 things that can give you cancer – the full list

http://gu.com/p/4dk62

From their website

The 116 things that can give you cancer – the full list
Rocked by the news that processed meat could be terribly bad for you? Well, chimney sweeping, salted fish and fracking also appear on the list compiled by the International Agency for Research on Cancer
Aisha Gani and Benedict Nicholson
Published: 07:00 GMT+00:00 Wed 28 October 2015
Follow Aisha Gani
The World Health Organisation said processed meats are among the most carcinogenic substances along with cigarettes, alcohol, sunbeds and arsenic.
The World Health Organisation said processed meats are among the most carcinogenic substances along with cigarettes, alcohol, sunbeds and arsenic. Composite: Rex, Alamy
After Monday’s bombshell news from the World Health Organisation that bacon, ham and sausages are carcinogenic, you can be forgiven for wondering just what exactly is safe for you to come into contact with – let alone eat.

Handily, the International Agency for Research on Cancer – a body that collects and publishes cancer figures worldwide – has a list of the 116 substances and activities (for some of them are more verb than noun) that are now considered to cause cancer.

Processed meats rank alongside smoking as cancer causes – WHO

Red meat isn’t on the list – that only probably causes cancer. This is the IARC’s group 1 list – the stuff it says definitely is carcinogenic. The IARC splits the list into three categories, which it calls “exposure circumstances”, “mixtures” and “agents”.

Carcinogenic exposure circumstances

1 Tobacco smoking: The most common exposure to the stimulant, prepared from the leaves of the tobacco plant, is through burning it and smoking it from a cigarette or hookah pipe into the mouth and then releasing it. Smoking’s history dates back to as early as 5000–3000BC when the agricultural product began to be cultivated in South America.

2 Sunlamps and sunbeds: A tanning bed, a device that emits ultraviolet radiation for a cosmetic tan, can give humans overexposure to UV radiation, which can cause skin cancer, cataracts, and premature skin ageing.

3 Aluminium production: Increased lung and bladder cancer risks have been reported in workers in aluminium reduction plants. The fumes of chemicals the workers may inhale, and exposure to coal-tar pitch volatiles for long periods during the process, can cause cancer.

4 Arsenic in drinking water: The highly toxic chemical which is used to make certain alloys used in the manufacturing industry, can get into the drinking water supply, particularly in ground water. Arsenic is known to cause skin cancer, and linked to causing liver, lung, kidney, and bladder cancer.

5 Auramine production: Auramine can be used as an antiseptic agent as well as to make dyes. A study found there to be an excess of bladder tumours among men engaged in the manufacture of auramine, through inhaling harmful agents, such as formaldehyde and sulphur, during the manufacturing process.

6 Boot and shoe manufacture and repair: Linked to increased risk of nasal cancer and leukaemia, due to exposure to suspected carcinogens such as leather dust, benzene and other solvents, yet the risk of cancer in shoe manufacturing may vary depending on the duration and level of exposure.

Play Video. Duration: 00:16
7 Chimney sweeping: Cleaning chimneys of soot and dust, historically done by small boys who could climb the chimney but now done mechanically, could cause a very specific form of cancer – termed “chimney sweep” cancer. It could be caused by inhalation and accidental ingestion of coal and burnt wood fumes and residue.

8 Coal gasification: Studies of the cancer levels of workers who had occupational exposure to coal gasification – when coal is reacted with oxygen, steam and carbon dioxide to form a gas – showed there to be an excess of lung cancer.

9 Coal tar distillation: Derived from coal, coal-tar pitch is a thick black liquid that remains after the distillation of coal tar. It is used as a base for coatings and paint, in roofing and paving, and as a binder in asphalt products. Both coal tar and coal-tar pitch contain many chemical compounds, including carcinogens such as benzene. Human exposure to coal tars can be through inhalation, ingestion, and absorption through the skin. The general population can be exposed to coal tars in environmental contaminants.

10 Coke (fuel) production: Workers at coking plants and coal-tar production plants – where coal is refined to be used as a solid fuel – may be exposed to coke oven emissions, and have an excess risk of dying from lung cancer and kidney cancer.

A furniture-maker’s workshop
A furniture-maker’s workshop. Photograph: Sam Frost
11 Furniture and cabinet making: Furniture makers are shown to have a statistical increase in nasal cancer risk, with excessive exposure to wood dust, according to studies.

12 Haematite mining (underground) with exposure to radon: Mining hematite, an underground source of iron, workers are simultaneously exposed to radon – a radioactive carcinogen, which can cause a large increase in the risk of lung cancer.

How bad is meat for me? Frankly, the experts don’t know

13 Secondhand smoke: Otherwise known as passive smoking, a non-smoker’s risk of getting lung cancer can increase by a quarter by breathing in other people’s smoke. It may also increase the risk of cancers of the larynx (voice box) and pharynx (upper throat). It’s estimated that every year, secondhand smoke kills over 12,000 people in the UK from lung cancer, heart disease, stroke and the lung condition chronic obstructive pulmonary disease.

14 Iron and steel founding: Studies of iron and steel founding workers in various parts of the world showed them to have a significantly increased risk for lung cancer. Exposures in the iron and steel founding industry are complex and include a wide variety of known genotoxic and carcinogenic substances including metals and formaldehyde.

15 Isopropanol manufacture (strong-acid process): People in the isopropanol manufacturing industry may face an increased risk of developing cancer due to exposure to suspected carcinogens, such as diisopropyl sulphate, isopropyl oils and sulphuric acid. The colourless, flammable chemical compound with a strong odour has a wide variety of industrial, household and pharmaceutical uses. Isopropyl alcohol solution is found in rubbing alcohol, hand sanitiser, and disinfecting pads.

I’m not giving up my ham and mustard sandwich | Ann Robinson

16 Magenta dye manufacturing: The production of magenta dyes – purplish-red in colour and among the first synthetic dyes to be produced in the 1850s – has chemicals linked to bladder cancer. Yet some carcinogenic chemicals were banned from hair dyes in the 1970s.

17 Occupational exposure as a painter: Studies have found a link between work as a painter and risk of cancer. Deaths such as bladder cancer and leukaemia in such cases could have been from an exposure to benzene – a chemical at high levels that can cause cancer and found in paint production – mixed with other organic solvents. Cases of lung cancer may be from exposure to particles containing lead chromate and to asbestos in the paint trade.

18 Paving and roofing with coal-tar pitch: Paving with coal tar and coal-tar pitch may contain many chemical compounds, including carcinogens such as benzene.

A worker taps a rubber tree in Songon, Ivory Coast
A worker taps a rubber tree in Songon, Ivory Coast. Photograph: Thierry Gouegnon/Reuters
19 Rubber industry: Harvested mainly in the form of the latex from certain trees, the manufacturing process of stretchy material can cause the risk of developing cancer, caused by chemicals. Studies examining countries with workers in the rubber industry showed they were more likely to have cancers such as bladder cancer, lung cancer, and leukaemia.

20 Occupational exposure of strong inorganic acid mists containing sulphuric acid: The liquid aerosols formed by condensation of sulphuric acid vapour, which is highly corrosive, can cause a higher risk of getting lung cancer.

Carcinogenic mixtures

21 Naturally occurring mixtures of aflatoxins: Such toxins produced by certain species of fungi, are among the most carcinogenic substances known, and linked to increased risk of liver cancer.

Cans of beer on display in an off-licence
Cans of beer on display in an off-licence. Photograph: Christopher Furlong/Getty Images
22 Alcoholic beverages: Alcoholic beverage consumption is a cause of breast, colorectal, larynx, liver, oesophagus, oral cavity and pharynx cancers, and as a probable cause of pancreatic cancer, as classified by the IARC.

23 Areca nut: Areca nut is a mild stimulant, akin to coffee, that is chewed with betel leaf. It is known to cause increased risk of mouth and oesophageal cancer.

24 Betel quid without tobacco: A leaf indigenous to Asia, is chewed with areca nut as a stimulant and can increase the risk of oral cancer.

25 Betel quid with tobacco: Betel can increase the risk of oral cancer.

26 Coal-tar pitches: This thick black liquid contains many chemical compounds, including carcinogens such as benzene.

27 Coal tars: Coal tar, a bi-product of coke production, contains many chemical compounds, including benzene.

Hazelwood coal mines in Morwell, Australia
Hazelwood coal mines in Morwell, Australia. Photograph: Meredith O’Shea for the Guardian
28 Indoor emissions from household combustion of coal: Coal is one of the most well-known carcinogens in the public consciousness, due to the prevalence of cancer in miners. It is a risk if coal dust produced from old-fashioned coal-burning fires is inhaled.

29 Diesel exhaust: There is a cancer risk from inhaling exhaust fumes produced by a diesel internal combustion engine. Over 30 components of diesel oil are listed at various levels of carcinogenic by the IARC.

30 Mineral oils, untreated and mildly treated: The World Health Organisation classifies untreated or mildly treated mineral oils as group-1 carcinogens to humans. Highly refined oils are classified as group-3, meaning they are not suspected to be carcinogenic, yet due to insufficient findings, cannot be classified as harmless.

Ground to dust: fracking, silicosis and the politics of public health

31 Phenacetin, analgesic mixtures containing: Studies on this pain- and fever-reducing drug, now banned in some countries link it with renal, pelvic and other urothelial tumours in patients.

32 Plants containing aristolochic acid: Used in Chinese herbal medicine for centuries, this plant extract is found to cause kidney disease and urothelial cancer.

33 Polychlorinated biphenyls (PCBs): This synthetic compound, widely used in electrical equipment in the past, was banned at the end of the 1970s in many countries because of environmental concerns. Studies of PCBs in humans have found increased rates of melanomas, liver cancer, gall bladder cancer, biliary tract cancer, gastrointestinal tract cancer, and brain cancer, and may be linked to breast cancer. PCBs are known to cause a variety of cancers in animals.

34 Chinese-style salted fish: Diets that are very high in salt-cured meats and fish, or pickled foods – which are more common in parts of Asia and northern Africa – can increase the risk of nasopharyngeal cancer, related to the upper part of the throat behind the nose. These foods can be very high in nitrates and nitrites, which react with protein to form nitrosamines. These chemicals can damage DNA.

The hydraulic fracturing test site operated by Cuadrilla in Balcombe, England
A police officer stands guard on the perimeter of the hydraulic fracturing test site operated by Cuadrilla in Balcombe, England. Photograph: Leon Neal/AFP/Getty Images
35 Shale oils: The development of shale gas, including fracking, may release toxic chemicals into air, water and soil during the process. Chemicals used in fracking are known to be of concern and have been linked to an increased risk of cancer. Benzene, acrylamide, and formaldehyde are all listed by the IARC as human carcinogens.

36 Soots: Coal dust, principally from the burning of coal, had contributed to a specific chimney sweep cancer that was prevalent in the 19th century.

37 Smokeless tobacco products: Tobacco chewed as a stimulant, sometimes with other leaves such as betel, is specifically linked to cancers of the larynx and the mouth.

38 Wood dust: Awareness of wood dust as a carcinogen and cause of nasal cancer is on the rise. In 2011 a cabinet maker’s widow successfully sued for £375,000 after her husband’s death.

Something is going to kill you. Life is about what happens before that | JC Johnson

39 Processed meat: Meat that is cured or treated in some way, either for preservation or taste. Examples include ham, bacon and sausages. It was ranked as dangerous as tobacco in October 2015 by the World Health Organisation (WHO), with specific links to bowel cancer.

Carcinogenic agents and groups of agents

40 Acetaldehyde

41 4-Aminobiphenyl

42 Aristolochic acids and plants containing them

43 Arsenic and arsenic compounds

44 Asbestos

45 Azathioprine

46 Benzene

47 Benzidine

48 Benzo[a]pyrene

‘It’s scaremongering’: the world’s meatiest places react to WHO report

49 Beryllium and beryllium compounds

50 Chlornapazine (N,N-Bis(2-chloroethyl)-2-naphthylamine)

51 Bis(chloromethyl)ether

52 Chloromethyl methyl ether

53 1,3-Butadiene

54 1,4-Butanediol dimethanesulfonate (Busulphan, Myleran)

55 Cadmium and cadmium compounds

56 Chlorambucil

57 Methyl-CCNU (1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; Semustine)

58 Chromium(VI) compounds

59 Ciclosporin

60 Contraceptives, hormonal, combined forms (those containing both oestrogen and a progestogen)

Contraceptive pills
Contraceptive pills. Photograph: Yay Media AS/Alamy
61 Contraceptives, oral, sequential forms of hormonal contraception (a period of oestrogen-only followed by a period of both oestrogen and a progestogen)

62 Cyclophosphamide

63 Diethylstilboestrol

64 Dyes metabolized to benzidine

65 Epstein-Barr virus

66 Oestrogens, nonsteroidal

67 Oestrogens, steroidal

68 Oestrogen therapy, postmenopausal

69 Ethanol in alcoholic beverages

70 Erionite

71 Ethylene oxide

72 Etoposide alone and in combination with cisplatin and bleomycin

The Kingdom by Damien Hirst
A tiger shark in formaldehyde (The Kingdom by Damien Hirst). Photograph: Sotheby’s/PA
73 Formaldehyde

74 Gallium arsenide

75 Helicobacter pylori (infection with)

76 Hepatitis B virus (chronic infection with)

77 Hepatitis C virus (chronic infection with)

78 Herbal remedies containing plant species of the genus Aristolochia

Food industry greets cancer links with a shrug – it’s been here before

79 Human immunodeficiency virus type 1 (infection with)

80 Human papillomavirus type 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 66

81 Human T-cell lymphotropic virus type-I

82 Melphalan

83 Methoxsalen (8-Methoxypsoralen) plus ultraviolet A-radiation

84 4,4’-methylene-bis(2-chloroaniline) (MOCA)

85 MOPP and other combined chemotherapy including alkylating agents

86 Mustard gas (sulphur mustard)

87 2-Naphthylamine

88 Neutron radiation

89 Nickel compounds

90 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)

91 N-Nitrosonornicotine (NNN)

92 Opisthorchis viverrini (infection with)

A woman wears a mask in front of Harbin railway station in China
A woman wears a mask in front of Harbin railway station in China as thick smog envelops the city. Photograph: Tao Zhang/Demotix/Corbis
93 Outdoor air pollution

94 Particulate matter in outdoor air pollution

95 Phosphorus-32, as phosphate

Addictive and probably carcinogenic: scientist reveals dangers of Daily Mail | Dean Burnett

96 Plutonium-239 and its decay products (may contain plutonium-240 and other isotopes), as aerosols

97 Radioiodines, short-lived isotopes, including iodine-131, from atomic reactor accidents and nuclear weapons detonation (exposure during childhood)

98 Radionuclides, α-particle-emitting, internally deposited

99 Radionuclides, β-particle-emitting, internally deposited

100 Radium-224 and its decay products

101 Radium-226 and its decay products

102 Radium-228 and its decay products

103 Radon-222 and its decay products

104 Schistosoma haematobium (infection with)

105 Silica, crystalline (inhaled in the form of quartz or cristobalite from occupational sources)

The sun
The sun, source of solar radiation. Photograph: Nasa/Soho/EPA
106 Solar radiation

107 Talc containing asbestiform fibres

108 Tamoxifen

Health threat of sugar is vastly underestimated, study claims

109 2,3,7,8-tetrachlorodibenzo-para-dioxin

110 Thiotepa (1,1’,1”-phosphinothioylidynetrisaziridine)

111 Thorium-232 and its decay products, administered intravenously as a colloidal dispersion of thorium-232 dioxide

112 Treosulfan

113 Ortho-toluidine

114 Vinyl chloride

115 Ultraviolet radiation

116 X-radiation and gamma radiation

Young black women have a higher frequency of BRCA mutations than previously reported — ScienceDaily

From Science Daily

Young black women are more likely to have aggressive types of breast cancer compared to non-Hispanic white women, … Women who have inherited mutations in the BRCA1 or BRCA2 genes are more likely to develop breast cancer or ovarian cancer, especially at a younger age. Approximately 5 percent of women with breast cancer in the United States have mutations in BRCA1 or BRCA2 based on estimates in non-Hispanic white women. Moffitt Cancer Center researchers  … discovered that 12.4 percent of the participants (young black women diagnosed with breast cancer at or below age 50) had mutations in either BRCA1 or BRCA2.

 

http://www.sciencedaily.com/releases/2015/08/150825095049.htm

Early research findings suggest screening for lung cancer might be helpful for some categories

PLOS Medicine: Evaluation of the Lung Cancer Risks at Which to Screen Ever- and Never-Smokers: Screening Rules Applied to the PLCO and NLST Cohorts

Evaluation of the Lung Cancer Risks at Which to Screen Ever- and Never-Smokers: Screening Rules Applied to the PLCO and NLST Cohorts

Currently the recommendation is that never-smokers should not be screened.

Smokers aged ≥65–80 y are a high-risk group who may benefit from screening –

 

It should be remembered that this study compared screening by CT scan VS screening by CXR.

Widely accepted opinion is that the statistical risk of lung cancer has returned to normal in ex-smokers who quit more than 15 years ago however this study suggests – but does not prove – that the lung cancer risk continues beyond that.

Cancer Screening

Epidemiology & Commonest Cancers

Cancer Risk Factors – Family History

Cancer Risk Factors – Modifiable / Lifestyle

Cancer Risk Factors – Past Medical History / Non-Modifiable

National Screening Programmes

Advanced Cancer Screening or Early Detection

Symptom Triage Tools